Abstract
Five complexes of copper(II) 4,4-diaminodiphenylsulphone have been synthesized. Copper salts of counter ion (sulphate, nitrate, chloride) and different reaction media (solvents) were used for the synthesis. The complexes varied in colour and composition. The compounds were characterized by conductivity, IR, UV, NMR and mass spectroscopies. The ligand coordinated to metal ion in a monodentate and bidentate manner. All the five complexes have tetrahedral configuration. The biological activities data showed that the complexes are more active against Esherichia coli, Klebbsiella pneumoniae and Staphylococcus aureus than the free ligand (4,4- diaminodiphenyl sulphone). Antimalaria activities of the complexes and the ligand were investigated using mice infected with Plasmodium berghei. All the complexes exhibited lower activity than the ligand and chloroquine. The effect of administration of the complexes on alkaline phosphatase activities of kidney, liver and serum of Albino rats were investigated. The serum ALP activity showed no significant change (P> 0.05), suggesting non-damaging effect on the plasma membrane of liver and kidney cells.