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E-Journal of Chemistry
Volume 6, S1, Pages S97-S102

In Silico Screening, Synthesis and In Vitro Evaluation of Some Quinazolinone and Pyridine Derivatives as Dihydrofolate Reductase Inhibitors for Anticancer Activity

A. G. Nerkar,1 A. K. Saxena,2 S. A. Ghone,1 and A. K. Thaker1

1Deptartment of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Vile Parle(w), Mumbai-400056, (M.S.), India
2Indian Institute of Integrative Medicine (RRL), Jammu, (Jammu), India

Received 27 February 2009; Accepted 4 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Hamdy M. Abdel-Rahman, Mohamed Abdel-Aziz, Joshua C. Canzoneri, Bernard D. Gary, and Gary A. Piazza, “ Novel Quinazolin-4(3 H )-one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies ,” Archiv der Pharmazie, 2014. View at Publisher · View at Google Scholar
  • Tamer Nasr, Samir Bondock, and Mahmoud Youns, “Anticancer activity of new coumarin substituted hydrazide-hydrazone derivatives,” European Journal of Medicinal Chemistry, 2014. View at Publisher · View at Google Scholar
  • Maryam Zahedifard, Fadhil Lafta Faraj, Mohammadjavad Paydar, Chung Yeng Looi, Maryam Hajrezaei, Mohadeseh Hasanpourghadi, Behnam Kamalidehghan, Nazia Abdul Majid, Hapipah Mohd Ali, and Mahmood Ameen Abdulla, “Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways,” Scientific Reports, vol. 5, pp. 11544, 2015. View at Publisher · View at Google Scholar
  • Mostafa M. Ghorab, Fatma A. Ragab, Helmy I. Heiba, and Aiten M. Soliman, “Design and synthesis of some novel 4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide derivatives as anticancer and radiose,” European Journal Of Medicinal Chemistry, vol. 117, pp. 8–18, 2016. View at Publisher · View at Google Scholar
  • Shagufta Shagufta, and Irshad Ahmad, “An insight into the therapeutic potential of quinazoline derivatives as anticancer agents,” Med. Chem. Commun., 2017. View at Publisher · View at Google Scholar
  • Mohamed H. Hekal, and Fatma S. M. Abu El-Azm, “New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation,” Synthetic Communications, vol. 48, no. 18, pp. 2391–2402, 2018. View at Publisher · View at Google Scholar