Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 515203 | 5 pages | https://doi.org/10.1155/2009/515203

Validated Spectrophotometric Estimation of Famciclovir in Tablet Dosage Form

Received05 Dec 2008
Accepted05 Feb 2009

Abstract

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Famciclovir (FCR) in bulk and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as orange II (OG-II) and alizarin red S (AR-S) in acidic medium followed by their extraction with chloroform to give colored chromogen with absorption maxima at 480 nm and 440 nm respectively. Beer’s law is valid in the concentration range of 2-10 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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