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E-Journal of Chemistry
Volume 6, Issue 4, Pages 1200-1204

In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

P. B. Mallikharjuna and Y. N. Seetharam

Laboratory of Biosystematics and Medicinal Plants, Department of PG Studies & Research in Botany, Gulbarga University, Gulbarga-585 106, India

Received 3 December 2008; Revised 8 March 2009; Accepted 20 March 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alkaloid fractions isolated from Strychnos potatorum L.f. (Loganiaceae) seed were tested for their antimicrobial properties against some pathogenic gram positive, gram negative and acid-fast bacteria and fungi. These fractions have shown considerable antimicrobial activity against both bacteria and fungi at the tested concentrations (100 & 200 μg/mL). Further, the growth of Proteus vulgaris, taphylococcus aureus, Salmonella typhimurium, Vibrio cholerae, Mycobacterium tuberculosis, Aspergillus niger and Candida albicans were significantly inhibited. These findings have confirmed the use of this plant in treating of several microbial infections both in traditional and folk medicine in India.