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E-Journal of Chemistry
Volume 6 (2009), S1, Pages S75-S78

Synthesis of Schiff Bases via Environmentally Benign and Energy-Efficient Greener Methodologies

Arshi Naqvi,1 Mohd. Shahnawaaz,1 Arikatla V. Rao,1 Daya S. Seth,1 and Nawal K. Sharma2

1School of Chemical Sciences, Department of Chemistry, St. John's College, Agra-282002, India
2Department of Bioengineering, University of Pittsburgh, 260, Kappa Drive, RIDC Park, Pittsburgh, PA 15234, USA

Received 13 February 2009; Accepted 10 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Non classical methods (water based reaction, microwave and grindstone chemistry) were used for the preparation of Schiff bases from 3-chloro-4-fluoro aniline and several benzaldehydes. The key raw materials were allowed to react in water, under microwave irradiation and grindstone. These methodologies constitute an energy-efficient and environmentally benign greener chemistry version of the classical condensation reactions for Schiff bases formation.