Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 604203 | 5 pages | https://doi.org/10.1155/2009/604203

Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivatives and their Schiff's Bases

Received08 May 2009
Accepted06 Jul 2009

Abstract

Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by 1H NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Staphylococcus aureus ATCC - 25923, ATCC - 441 and Bacillus subtilis ATCC- 6633 as gram positive, Escherichia coli ATCC - 11775 and Pseudomonas aeruginosa ATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilis and S. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coli and P. Aeruginosa) MIC values between 25 and 200 mg/mL.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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