Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 624150 | https://doi.org/10.1155/2009/624150

R. T. Vashi, S. B. Patel, "Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes", Journal of Chemistry, vol. 6, Article ID 624150, 7 pages, 2009. https://doi.org/10.1155/2009/624150

Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes

Received24 Feb 2009
Accepted20 Apr 2009

Abstract

Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-4-one and 2-chloromethyl–3-(methyl phenyl)-6-bromo-3(H)-quinazoline-4-one. Both these compounds were condensed with 5-amino-8-hydroxyquinoline. The so called resulted compounds were named respectively as 2-[(8-hydroxy-quinolinyl) –5- amino methyl] -3-(4-methylphenyl)- 3(H)- quinazoline -4- one and 2-[(8-hydroxyquinolinyl)-5-aminomethyl] -3(methyl phenyl)-6-bromo-3(H)-quinazoline-4-one. Both the compounds were designated respectively as HL1 and HL2 ligands. The transition metal (Cu2+, Ni2+, Zn2+, Mn2+ and Co2+) complexes of both these ligands were prepared. The ligands and their complexes as case may be were characterized by elemental analysis, spectral studies and number of hydroxyl groups. The stoichiometry of the complexes has been found to be 1:2 (metal: ligand). An octahedral geometry around Co2+, Ni2+ and Mn2+, distorted octahedral geometry around Cu2+ and tetrahedral geometry of around Zn2+ have been proposed. These complexes also been tested for their antifungal activities.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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