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E-Journal of Chemistry
Volume 6 (2009), S1, Pages S17-S20

Compatibility Study of Lamivudine with Various Cellulose Polymers

P. Narayana Raju,1 K. Prakash,2 and M. Lakshmi Narasu3

1KLR College of Pharmacy, Paloncha, Khamman Dist., Andhrpradesh, India
2Faculty of Pharmacy, 7th April University, Zawia, Libya
3Centre for Biotechnology, Institute of Science and Technology, JNTU, Kukatpally, Hyderabad, Andhra Pradesh, India

Received 2 April 2009; Accepted 5 June 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


For the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excepients. Differential scanning calorimetry (DSC) and FTIR were the common methods for the study of compatibility. Isothermal stress testing (IST) is also a method for the compatibility study during proto type formulation. In the present study drug excepient compatibility study of lamivudine was conducted with different controlled release polymers. The drug and polymer mixtures were stored at 50 °C for 2 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that lamivudine was compatible with the all the polymers used in the study. The polymers used in the present study were definitely incorporated in the extended release lamivudine formulation.