Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 787150 | 8 pages | https://doi.org/10.1155/2009/787150

Synthesis, Characterization and Antimicrobial Properties of Schiff Bases Derived from Condensation of 8-Formyl-7-hydroxy-4-methylcoumarin and Substituted Triazole Derivatives

Received03 Jun 2009
Accepted01 Aug 2009

Abstract

Two biologically active classes of compounds coumarins and triazoles were employed to form the Schiff bases. The synthesized Schiff base viz., 3-aryl-[(1-isocyano-4-methyl-7-hydroxycoumarin)]-5-methyl-1,3,4-triazoline-2-one and its substituents were obtained by the condensation of amino group of mono and disubstituted derivatives of 3-methyl-5-oxo-1,2, 4-triazoles with 8-formyl-7-hydroxy-4-methylcoumarin in alcohol. The characterization were studied by elemental analysis, IR, 1H NMR and mass spectra. The biological activities of the compounds were assayed against two bacterial via, B. subtilis, E.coli and two fungal strains A. niger, C.albican. The results indicate that the present compounds may serve as better fungicides when compared to bactericides. The synthesized compounds have turned to be wonder compounds possessing antimicrobial properties.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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