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E-Journal of Chemistry
Volume 6, Issue 4, Pages 1117-1120
http://dx.doi.org/10.1155/2009/790531

UV Spectrophotometric Estimation of Acipimox inBulk and Capsule Dosage Form

A. Elphine Prabahar,1 B. Thangabalan,1 R. Kalaichelvi,2 and P. Vijayaraj Kumar3

1Department of Pharmacy, Donbosco PG College, Vatticherukuru Mandal, Guntur-522 017, India
2K.C. Reddy Institute of Pharmaceuatical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur-522 348, India
3Bharat Instite of Pharmacy, Mangalpally Village, Ibrahimpatnam, PR Dist.-501506, India

Received 18 February 2009; Accepted 15 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for determination of acipimox (ACX) in bulk and capsule dosage form. Acipimox exhibited maximum absorbance at 231 nm with apparent molar absorptivity of 1.5104 × 104 in distilled water. Beer’s law was found to be obeyed in the concentration range 1-10 μg mL-1. Correlation coefficient was found to be 0.9998. The developed method was validated respect to linearity, precision, accuracy. The proposed method is useful for the routine estimation of ACX in bulk and capsule dosage form.