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E-Journal of Chemistry
Volume 6, S1, Pages S25-S32
http://dx.doi.org/10.1155/2009/934706

Microwave Assisted Liquid Phase Synthesis of Benzimidazolo Benzothiophenes for Antimicrobial Activity

Deepthi Kini, Harish Kumar, and Manjunath Ghate

Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore, Karnataka-560035, India

Received 30 April 2009; Accepted 25 June 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Benzimidazolo benzothiophene derivatives were prepared by liquid phase combinatorial synthesis using soluble polymer support PEG 5000 and 4-fluoro-3-nitrobenzoic acid as starting materials with substituted primary amines. All these synthesized compounds were established by the spectral data and tested for antimicrobial activity against gram positive bacteria, i.e. S. aureus, B. subtilis and gram negative bacteria, E.coli and P.aeruginosa and anti fungal activity against C. albicans. Ampicillin and ciprofloxacin were used as standard for antibacterial activity and cotrimoxazole for anti fungal activity. Compared with standards compounds (1a-h) showed significant activity against bacterial species and 1g showed significant activity against fungal species.