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E-Journal of Chemistry
Volume 7 (2010), Issue 2, Pages 383-390

Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one

B. Lakshminarayanan,1 V. Rajamanickam,2 T. Subburaju,1 and L. A. Pradeep Rajkumar1

1Karpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, India
2Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, India

Received 31 July 2009; Accepted 20 September 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.