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E-Journal of Chemistry
Volume 7 (2010), Issue 3, Pages 997-1002

Chemometrics-Assisted Simultaneous Determination of Atenolol and Furosemide in Synthetic Binary Mixtures and Combined Tablet Preparations

Amir H. M. Sarrafi, Elahe Konoz, and Alireza Feyzbakhsh

Department of Chemistry, Faculty of Science, Islamic Azad University-Central Tehran Branch, Simaye Iran St., San’at Square, Tehran, Iran

Received 16 November 2009; Accepted 10 January 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this work a numerical method, based on the use of spectrophotometric data coupled to PLS multivariate calibration, is reported for the simultaneous determination of furosemide (FUR) and atenolol (ATE) in synthetic samples and combined commercial tablets. The correlation coefficients (R2) and recovery range for ATE and FUR in synthetic mixtures were 0.9938, 0.9949 and 94.72-103.72%, 95.60-104.34% respectively. The results of optimized method in combined tablet preparations compared with British Pharmacopeia 2007 standard methods that have a good agreement. The proposed method are simple, fast, inexpensive and do not need to any separation or preparation methods.