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Synthesis and Antimicrobial Activity of Some Novel Schiff Bases Containing 1,2,4-Triazole-3-thione
M. M. Çalisir,1 B. Koçyigit-kaymakçioglu
,1 B. Özbek,2 and G. ÖtÜk21Marmara University, Faculty of Pharmacy Department of Pharmaceutical Chemistry, İstanbul, Turkey
2Istanbul University, Faculty of Pharmacy Department of Pharmaceutical Microbiology, İstanbul, Turkey
Abstract
A series of Schiff bases (4a-j) were prepared by reacting 4-amino-5-(1-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and substituted aromatic aldehydes. The chemical structures were confirmed by means of UV, 1H NMR, IR, MS(API-ES) spectral data and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. Among the tested compounds, Schiff bases with 4-OH and 4-NO2 substituent exhibited remarkable antimicrobial activity against all the tested microorganism.
Copyright
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
