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E-Journal of Chemistry
Volume 7 (2010), S1, Pages S458-S464

Synthesis and Antimicrobial Activity of Some Novel Schiff Bases Containing 1,2,4-Triazole-3-thione

M. M. Çalisir,1 B. Koçyigit-kaymakçioglu,1 B. Özbek,2 and G. ÖtÜk2

1Marmara University, Faculty of Pharmacy Department of Pharmaceutical Chemistry, İstanbul, Turkey
2Istanbul University, Faculty of Pharmacy Department of Pharmaceutical Microbiology, İstanbul, Turkey

Received 25 December 2009; Accepted 24 February 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of Schiff bases (4a-j) were prepared by reacting 4-amino-5-(1-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and substituted aromatic aldehydes. The chemical structures were confirmed by means of UV, 1H NMR, IR, MS(API-ES) spectral data and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. Among the tested compounds, Schiff bases with 4-OH and 4-NO2 substituent exhibited remarkable antimicrobial activity against all the tested microorganism.