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E-Journal of Chemistry
Volume 7 (2010), Issue 1, Pages 101-104

Spectrophotometric Determination of Ezetimibe

P. Baby Sudha Lakshmi, D. Ramchandran, and C. Rambabu

Department of Chemistry, Acharya Nagarjuna University, Nuzvid Campus, Nuzvid-521201. A.P, India

Received 29 May 2009; Accepted 11 July 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. Method A and B are based on the redox/complex formation reaction of drug with 1,10-phenanthroline and hexacyano-ferrate(III) in presence of ferric chloride to form coloured chromogens exhibiting λmax at 510 and 740 nm respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The results are compared with those obtained using UV spectrophotometric method in alcohol at 231.7 nm.