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E-Journal of Chemistry
Volume 7 (2010), Issue 1, Pages 166-170

Electrochemical Reduction Behaviour of Zileuton at a Dropping Mercury Electrode by Polarography

N. Y. Sreedhar, M. Sankara Nayak, K. Srinivasa Prasad, P. R. Prasad, and C. Nageswar Reddy

Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati, A.P, India

Received 27 March 2009; Revised 3 June 2009; Accepted 1 August 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Electrochemical behaviour of anticancer drug zileuton was investigated by direct current polarography (DCP) and differential pulse polarography using a dropping mercury electrode (DME) as working electrode and Ag/AgCl reference electrode in universal buffer of pH range from 2.0 to 12.0. The drug was extracted from the dosage forms in dimethyl formamide (DMF). Kinetic parameters such as diffusion co-efficient (D) and heterogeneous forward rate constants (k0f,h) are evaluated and reported. The differential pulse polarographic method has been developed for the determination of this drug in pharmaceutical formulations.