Electrochemical Reduction Behaviour of Zileuton  at a Dropping Mercury Electrode by Polarography

Sreedhar, N. Y.; Nayak, M. Sankara; Prasad, K. Srinivasa; Prasad, P. R.; Reddy, C. Nageswar

doi:https://doi.org/10.1155/2010/251415

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Volume 7 | Article ID 251415 | https://doi.org/10.1155/2010/251415

Electrochemical Reduction Behaviour of Zileuton at a Dropping Mercury Electrode by Polarography

N. Y. Sreedhar,¹M. Sankara Nayak,¹K. Srinivasa Prasad,¹P. R. Prasad,¹and C. Nageswar Reddy¹

Received27 Mar 2009

Revised03 Jun 2009

Accepted01 Aug 2009

Abstract

Electrochemical behaviour of anticancer drug zileuton was investigated by direct current polarography (DCP) and differential pulse polarography using a dropping mercury electrode (DME) as working electrode and Ag/AgCl reference electrode in universal buffer of pH range from 2.0 to 12.0. The drug was extracted from the dosage forms in dimethyl formamide (DMF). Kinetic parameters such as diffusion co-efficient (D) and heterogeneous forward rate constants (k⁰f,h) are evaluated and reported. The differential pulse polarographic method has been developed for the determination of this drug in pharmaceutical formulations.

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Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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