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Synthesis of Some 2-Thioxo-imidazolidin-4-one Derivatives and its Antimicrobial Activity
A. Jamal Abdul Nasser
,1 A. Idhayadhulla,1 R. Surendra Kumar,1 and J. Selvin21P.G & Research Department of Chemistry, Jamal Mohamed College, Tiruchirapalli-620020, Tamilnadu, India
2Department of Microbiology, Bharathidasan University, Tiruchirapalli-620024, Tamilnadu, India
Abstract
Series of newly prepared 3-{[2,6-bis(4-substituted phenyl)-1- methylpiperidin-4- ylidene] amino}- 2-thioxo-imidazolidin-4-one derivatives (3a-3f) have been synthesized by the cyclization of compound (2a-2f), ethyl chloro acetate and fused sodium acetate. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. The synthesized compounds were screened for their antimicrobial activity against four antibacterial and four antifungal organisms.
Copyright
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
