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E-Journal of Chemistry
Volume 7 (2010), Issue 1, Pages 227-233
http://dx.doi.org/10.1155/2010/293287

Template Synthesis, Characterization and Biological Activity of Cu(II), Ni(II), Co(II), Zn(II)Complexes with Isonicotinoylhydrazone--2-aldehydefluorene Ligand

Received 30 May 2009; Accepted 20 July 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This is about synthesizing new complex combinations of Cu(II), Ni(II),Co(II), Zn(II) with aroylhydrazone ligand isonicotinoylhydrazone-2-aldehydefluorene (INHAF) made by condensation of isonicotinoylhydrazine with 2-aldehydefluorene. The complexes have been characterized by analytical data, IR, UV-Vis, NMR spectra, magnetic susceptibility values, thermal analysis and for the Cu(II) complex the ESR spectrum has been registered. For all complexes the biological activity against the Staphylo-coccus aureus, Escherichia coli, Klebssiella pneumoniae bacteria has been investigated. The experimental data sustain stoichiometry of 1:2 (metal/ligand) for the Cu(II), Ni(II), Zn(II) complexes and of 1:1 for the complex with Co(II). The electronic spectra and the magnetic moments suggest octahedral stereochemistry at the complexes with Cu(II), Ni(II) and the tetrahedral geometry for the Co(II) complex. The INHAF ligand is coordinated bidentate by the O=C amide oxygen and the azomethine nitrogen in the complexes of Cu(II), Ni(II), Co(II) and monodentate by the azomethine nitrogen in the complex of Zn(II).