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E-Journal of Chemistry
Volume 7, Issue 3, Pages 1080-1084
http://dx.doi.org/10.1155/2010/294096

A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC

A. A. Heda, A. R. Sonawane, G. H. Naranje, and P. K. Puranik

Department of Pharmaceutics, Government College of Pharmacy, Vedant road, Osmanpura, Aurangabad-431005 (M.S.), India

Received 14 October 2009; Accepted 7 December 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, selective, rapid and precise reverse phase high pressure liquid chromatographic method has been developed for the estimation of cinnarizine from pharmaceutical formulation. The method was developed using MICRA-NPS C18 (length×OD×ID =33×8.0×6.0 mm, 1.5 μm) column with a mobile phase consisting of acetonitrile, triethylamine buffer (adjusted to pH 4.5 with 10% w/v potassium hydroxide) and tetrahydrofuran in the ratio 30:66:4 respectively, at a flow rate of 0.5 mL/min. Wavelength was fixed at 253 nm. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the routine estimation of cinnarizine in pharmaceutical dosage form.