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E-Journal of Chemistry
Volume 7, Issue 2, Pages 655-664

Synthesis of Thienopyrimidines and their Antipsychotic Activity

Chanchal Sharma, Swapnil Yerande, Rajashree Chavan, and A. V. Bhosale

Department of Pharmaceutical Chemistry, Poona District Education Association’s Seth Govind Raghunath, Sable College of Pharmacy, Saswad, Dist. Pune, Maharashtra-412 301, India

Received 12 August 2009; Accepted 5 October 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of thienopyrimidines and related heterocycles were synthesized by refluxing related imidoyl chloride with primary and secondary amines under microwave irradiation and classical heating. The imidoyl chlorides were synthesized from corresponding cyclic imides with phosphorus oxychlorides under microwave irradiation and classical heating. The structures of the compounds were confirmed by FT-IR, NMR. The synthesized compounds were screened for anti psychotic activity.