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E-Journal of Chemistry
Volume 7, Issue 2, Pages 433-436

Synthesis, Spectral Studies and Anti-Inflammatory Activity of 2-Acetyl Thiophene

B. Ramesh and B. Someswara Rao

Department of Pharmaceutical Chemistry, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, India

Received 19 August 2009; Accepted 10 October 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some new chalcones have been synthesized by the condensation of 2-acetyl thiophene with various aromatic aldehydes in 40% alkali. The synthesized compounds were identified by spectral data and screened for anti-inflammatory activity. Some of these compounds showed moderate to considerable anti-inflammatory activity.