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E-Journal of Chemistry
Volume 7 (2010), S1, Pages S43-S48
http://dx.doi.org/10.1155/2010/418279

Polarographic Analysis of Structurally Modified Paracetamol

Rakesh Choure and K. S. Pitre

Department of Chemistry, Dr. Hari Singh Gour University, Sagar M.P.470003, India

Received 25 December 2009; Revised 20 March 2010; Accepted 21 April 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Paracetamol is an analgesic drug. Its potency may be increased by modifying the drug by way of molecular modification. In the present study the drug has been modified by its complex formation with methanol and other organic compounds. The drug organic compound interaction has been studied using differential pulse polarography and direct current polarography. In Britton Robinson buffer as supporting electrolyte of pH 7.2±0.1, paracetamol produced a well defined peak at -1.18v and it’s modified forms at relatively higher negative value. The change in peak potential and lowering in peak height indicating drug organic compound complex formation.