Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 460185 | 7 pages | https://doi.org/10.1155/2010/460185

Low-level Determination of Residual Methyl Methane Sulfonate and Ethyl Methane Sulfonate in Pharmaceuticals by Gas Chromatography with Mass Spectrometry

Received08 Aug 2009
Accepted02 Oct 2009

Abstract

A capillary gas chromatographic method using mass spectrometric detection was developed and validated for the trace analysis (ppm level) of methyl methane sulfonate and ethyl methane sulfonate in pharmaceutical drug substances. The method utilizes a capillary column (DB-624) with 6% cyanopropyl phenyl and 94% dimethyl polysiloxane stationary phase. A dissolve-and-injection approach was adopted for sample introduction in a split less mode. Mixture of (80:20) ratio of methanol and chloroform was used as a diluent or sample solvent. A limit of detection of about 0.17 μg/g (0.17 ppm) for methyl methane sulfonate and 0.18 μg/g (0.18 ppm) for ethyl methane sulfonate were achieved and limit of quantitation of 0.52 μg/g (0.52 ppm) for methyl methane sulfonate and 0.54 μg/g (0.54 ppm) for ethyl methane sulfonate were achieved for alkyl sulfonates in drug substance samples.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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