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Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi, "Synthesis of Spiro Heterocyclic Compounds", Journal of Chemistry, vol. 7, Article ID 604549, 4 pages, 2010. https://doi.org/10.1155/2010/604549
Synthesis of Spiro Heterocyclic Compounds
Abstract
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines (IV & V) and spiropyrimidinethione (VI) respectively. The structures of the final products were established by physical and spectral means.
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Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
