Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi, "Synthesis of Spiro Heterocyclic Compounds", Journal of Chemistry, vol. 7, Article ID 604549, 4 pages, 2010. https://doi.org/10.1155/2010/604549
Synthesis of Spiro Heterocyclic Compounds
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines (IV & V) and spiropyrimidinethione (VI) respectively. The structures of the final products were established by physical and spectral means.
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