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E-Journal of Chemistry
Volume 7, Issue 3, Pages 899-907
http://dx.doi.org/10.1155/2010/760180

Microwave-Assisted Synthesis of Acetophenone (per-O-acetylated-β-D-glucopyranosyl)thiosemicarbazones

Nguyen Dinh Thanh, Nguyen Thi Kim Giang, and Le The Hoai

Faculty of Chemistry, College of Science, Hanoi National University, 19 Le Thanh Tong, Ha Noi-10000, Viet nam

Received 3 November 2009; Accepted 2 January 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thirteen new substituted acetophenone (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-thiosemicarbazones (3) were synthesized by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl thiosemicarbazide (1) and substituted acetophenones (2). The reaction was performed using microwave-assisted method. The compounds (3) have remarkable antibacterial and antifungal activities against Escherichia coli, Staphylococcus epidermidis and Candida albicans.