Acoustical and volumetric properties have been measured for substituted heterocyclic compounds digoxin and thiabendazole in 1, 4 dioxane at 303 K. The ultrasonic velocity measurement have been performed to evaluate acoustical parameter such as adiabatic compressibility (βs), partial molal volume (ɸv), intermolecular free length (Lf), apparent molal compressibility (ɸk), specific acoustic impedance (Z), relative association (RA), salvation number (Sn), limiting apparent molal compressibility (ɸ0k), limiting apparent molal volume(ɸ0v) and their constant (Sk,Sv). The viscosity coefficient (A, B) was evaluated by using john–dole equation. These parameters throw the light on the solute-solvent interaction and solute-solute interaction.