Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 807059 | https://doi.org/10.1155/2010/807059

R. S. Sodani, Prakash C. Choudhary, Hari Om Sharma, B. L. Verma, "Syntheses and Reactions of 4′-[(ω-Bromoalkyl)oxy]-and 4′,4′′′-(Polymethylenedoxy)-bis Substituted Chalcones", Journal of Chemistry, vol. 7, Article ID 807059, 7 pages, 2010. https://doi.org/10.1155/2010/807059

Syntheses and Reactions of 4′-[(ω-Bromoalkyl)oxy]-and 4′,4′′′-(Polymethylenedoxy)-bis Substituted Chalcones

Received30 Sep 2009
Accepted25 Nov 2009

Abstract

Base catalyzed condensation of 4-hydroxyacetophenone (1) with several aldehydes resulted 4′-hydroxychalcones (2a-c). Reaction of α,ω -dibromoalkanes (3, n=2, 4 & 6) with (2a-c) in equimolar ratio resulted a mixture of 4′-[(ω-bromoalkyl)oxy]- substituted chalcones (4a-i) and 4′,4′′′-(polymethylenedioxy)-bis substituted chalcones (5a-i) separated by ethanol as soluble (4a-i) and insoluble (5a-i) products. Compounds (5a-i) were also synthesized by another route. Compound 1 on treatment with 3 in molar ratio 2:1 resulted 4′,4′′′-(polymethylenedioxy)-diacetophenone (4#a-c) which on base catalyzed condensation gave compounds (5a-i). Reaction of 4d with substituted phenols and thiophenols gave corresponding phenoxy and thiophenoxy substituted chalcones (6a-f) where as compounds 5a, 5b, 5d, 5h and 5e on treatment with hydrazine hydrate furnished corresponding bis-2-pyrazolines (7a-e). The structures of all synthesized compounds were confirmed on the basis of analytical and spectral data.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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