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E-Journal of Chemistry
Volume 7 (2010), Issue 2, Pages 636-640

Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity

D. R. Harish Kumar and M. D. Karvekar

Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore-560035, India

Received 29 August 2009; Accepted 20 October 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b,3cand 3d exhibited moderate activity.