Synthesis, Characterisation, Spectral and Microbial Studies of Transition Metal Complexes of the Drug, Secnidazole
5-Chloromethyl-8-quinolinol hydrochloride was condensed with 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol in presence of potassium carbonate. The resulting 5-((1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy)methyl)quinolin-8-ol was characterized by elemental analysis and spectral studies. The transition metal chelates of the same were prepared with Cu2+, Ni2+, Co2+, Mn2+ and Zn2+ and characterized by IR and electronic spectral studies and magnetic properties. The antimicrobial activity of ligand and its metal chelates were screened against various gram positive and gram negative organisms. The results show that all these samples are more or less active agents against various organisms.
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.