Synthesis, Characterisation, Spectral and Microbial Studies of Transition Metal Complexes of the Drug, Secnidazole

Abstract

5-Chloromethyl-8-quinolinol hydrochloride was condensed with 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol in presence of potassium carbonate. The resulting 5-((1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy)methyl)quinolin-8-ol was characterized by elemental analysis and spectral studies. The transition metal chelates of the same were prepared with Cu²⁺, Ni²⁺, Co²⁺, Mn²⁺ and Zn²⁺ and characterized by IR and electronic spectral studies and magnetic properties. The antimicrobial activity of ligand and its metal chelates were screened against various gram positive and gram negative organisms. The results show that all these samples are more or less active agents against various organisms.