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E-Journal of Chemistry
Volume 7, Issue 4, Pages 1190-1195
http://dx.doi.org/10.1155/2010/947215

Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives

Vertika Gautam, Viney Chawla, Pankaj k. Sonar, and Shailendra K. Saraf

Faculty of Pharmacy, Northern India Engineering College, Lucknow-227105, Uttar Pradesh, India

Received 6 October 2009; Revised 17 December 2009; Accepted 10 February 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of 1, 3, 5-trisubustituted pyrazole derivatives were synthesized and screened for antimicrobial activity. The compounds (2j-o) were evaluated against two gram-positive and two gram-negative bacteria and one fungus, at concentrations of 10 µg/mL and 50 µg/mL. The compounds were founds to be inactive against P. aeruginosa and A. niger but exhibited moderate activity against B. subtilis, E. coli and S. aureus. It can be concluded that the newly synthesized compounds possess promising antimicrobial activity.