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E-Journal of Chemistry
Volume 8 (2011), Issue 1, Pages 391-399
http://dx.doi.org/10.1155/2011/195495

Simultaneous Determination by Gas Chromatography of Lindane and Carbaryl in Combined Formulations

Indrajit Sen, Ajay Shandil, Manjeet Aggarwal, and Rakesh Kumar Khandal

Shriram Institute for Industrial Research, 19 University Road, Delhi-110007, India

Received 18 January 2010; Revised 2 April 2010; Accepted 21 May 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A gas chromatographic method developed and validated for simultaneous determination of lindane and carbaryl for quality evaluation of lindane-carbaryl granule, using a glass capillary HP5 column (30 m x 0.32 mm; 0.25 μm), temperature programming with flame ionization detector and dibutylphthalate as an internal standard. The calibration graphs were found linear in the concentration range of 1 μg/mL to 1000 μg/mL for both lindane and carbaryl with correlation coefficient of 0.999 and 0.999 respectively and co-efficient of variation for intra-day and inter-day repeatability studies at different concentration levels was found to be less than 2%. The accuracy of method ranges between 98.5% to 100.8%. Specificity and robustness were also within the acceptable range. The method is highly sensitive with LOD and LOQ as 0.5 and 2 μg/mL for lindane and carbaryl respectively. The method has been tried on several formulations of lindane-carbaryl granules for quality control and has been found to be applicable.