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E-Journal of Chemistry
Volume 8, Issue 1, Pages 63-70
http://dx.doi.org/10.1155/2011/545313

Studies on Water-Polymer Interactions inthe Presence of Aceclofenac at 298.15 K

Siti S. B. Ambomase,1 Sushree Tripathy,1 Minaketan Tripathy,1 and Upendra N. Dash2

1Faculty of pharmacy, Campus Puncak AlamUniversiti Teknologi MARA (UiTM), Selangore-42300, Malaysia
2Department of Chemistry ITER, SOA University, Bhubaneswar-751030, India

Received 20 March 2010; Accepted 15 May 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Densities and ultrasonic velocities of aqueous mixtures of methyl cellulose (MC) and polyethylene glycol (PEG) and of methyl cellulose and hydroxyl propyl methyl cellulose (HPMC), over the compositions, 9:1, 8:2 and 6:4, and of MC, HPMC and PEG, over the compositions, 9:0.5:0.5, 8:1:1 and 6:2:2, have been measured with and without acelofenac at 298.15K and at atmospheric pressure. The experimental ultrasonic velocities have been used to determine isentropic compressibilities, apparent isentropic molar compressibilities, acoustic impedance, molar compressibility, molar sound velocity, free volume and relative association for the systems with and without aceclofenac. The results have been discussed in terms of solute solvent and solute-solute interactions and various structural effects.