P. Rashmi, Gopal Krishna Rao, Kshama Devi, B. G. Shivananda, G. R. Swetha, G. A. Suneetha, "Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics", Journal of Chemistry, vol. 8, Article ID 545403, 7 pages, 2011. https://doi.org/10.1155/2011/545403
Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics
The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives [4(a-h), 5] were prepared by Ullmann’s ether condensation. The structures of new compounds are supported by their IR, 1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound 3 has shown better antiinflammatory and analgesic activity.
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