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E-Journal of Chemistry
Volume 8 (2011), Issue 1, Pages 405-414

Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I

Reda M. Abdel-Rahman, Mohammad Saleh I. T. Makki, and Wafa A. Bawazir

Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah-21315, Saudi Arabia

Received 11 February 2010; Accepted 7 April 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five-membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4-triazole derivatives (3-13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a-f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare with Nystatin and Nalidixic acid.