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E-Journal of Chemistry
Volume 8 (2011), Issue 4, Pages 1944-1950

Chemical Studies on 3,6-Dichloropyridazine (Part 2)

N. M. Abd El-Salam,1 Z. Y. Al Shoaibi,2 and G. A. Ahmed3

1Department of Natural Sciences, Riyadh Community College, King Saud University, P.O.Box 28095, Riyadh-11437, Saudi Arabia
2Organic Chemistry Department, Faculty of Pharmacy, Sana'a University, Egypt
3Chemistry Department, Faculty of Science, Zagazig University, Egypt

Received 30 November 2010; Accepted 22 January 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


3,6-Dichloropyridazine (1) reacted with 2-aminophenol, phenylalanine, acetophenone hydrazone derivatives, acid hydrazide derivatives and amino-aromatic acids (anthranilic acid and 5-bromoanthranilic acid) and yield the compounds (2), (3), (4a,b), (5a,b) and (6a,b) respectively. Reaction of compounds (5a,b) with acid hydrazide gave (8a,b). Also, compounds (6a,b) reacted with aromatic amino acid and gave (7a-c).