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E-Journal of Chemistry
Volume 8, Issue 3, Pages 1120-1123

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

Bahram Letafat,1 Negar Mohammadhosseini,1 Ali Asadipour,2 and Alireza Foroumadi3

1Department of Chemistry, Islamshahr Branch, Islamic Azad University, Tehran, Iran
2Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
3Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Received 14 November 2010; Accepted 21 January 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.