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E-Journal of Chemistry
Volume 8, Issue 1, Pages 368-372

Phase Transfer Catalysis Assisted Thorpe Reaction for the Synthesis of 3-Aminothiophene-2-carboxylates

R. D. Shah

Chemistry Department, M. G. Science Institute, Navrangpura, Ahmedabad-380009, Gujarat, India

Received 30 March 2010; Accepted 24 May 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thorpe cyclization constructing synthetically important methyl or ethyl 3-amino-4-arylthiophene-2-carboxylates has been studied using eco friendly phase transfer catalysis technique. 3-Amino-4-arylthiophene-2-carboxylates have been synthesized from 3-hydroxy-2-arylacrylonitriles and thioglycolates under different solid-liquid phase-transfer conditions.