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E-Journal of Chemistry
Volume 8, Issue 1, Pages 312-318

Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions

Taoues Boumoud,1 Boudjemaa Boumoud,1 Paul Mosset,2 and Abdelmadjid Debache1

1Laboratoire des Produits Naturels d’origine Végétale et de SynthèseOrganique, Département de Chimie., Faculté des Sciences, Université Mentouri de Constantine 25000 Constantine, Algeria
2ENSChimie de Rennes, CNRS, UMR 6226, Avenue Gal LeclercCS 50837, 35708 Rennes Cedex 7, France

Received 23 April 2010; Accepted 17 June 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one-pot Biginelli condensation in the presence of gypsum as an environmental friendly and recycled catalyst.