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E-Journal of Chemistry
Volume 8, S1, Pages S149-S154

Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives

P. Panneerselvam and G. Geete Ganesh

Department of Pharmaceutical Chemistry, C.L.Baid Metha College of Pharmacy, Thoraipakkam, Chennai-600 097, Tamilnadu, India

Received 14 March 2011; Accepted 30 April 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR, 1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activity i.e. antibacterial activity against S. aureus and E. coli and antifungal activity against fungus A. nigar. Compounds G5 and G7 exhibited significant both antibacterial and antifungal activity while G2, G10 and G3, G9 showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.