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E-Journal of Chemistry
Volume 8, Issue 3, Pages 1456-1461
http://dx.doi.org/10.1155/2011/972359

A Novel Antimicrobial Phenanthrene Alkaloid from Bryopyllum pinnatum

Donatus Ebere Okwu and Fred Uchenna Nnamdi

Department of Chemistry, Michael Okpara University of Agriculture Umudike, P.M.B 7267 Umuahia Abia State, Nigeria

Received 3 June 2009; Accepted 1 August 2009

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Phenenthrene alkaloid identified as 1-ethanamino 7 hex-1-yne-5I-one phenanthrene was isolated from the ethanolic extract of the leaves of Bryophyllum pinnatum (syn. B. calcinum kalanchoe pinnata) a versatile Nigeria medicinal plant. The structure was elucidated using NMR, IR, UV and MS spectral data. Antimicrobial studies showed that the isolated compound successfully inhibited Psuedomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. This result authenticates the use of bryophyllum pinantum in phytomedicine for disease prevention and treatment of infections.