Journal of Chemistry

Journal of Chemistry / 2012 / Article

Open Access

Volume 9 |Article ID 156346 |

Sunakar Panda, Jagat Krushna Tripathy, "A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives", Journal of Chemistry, vol. 9, Article ID 156346, 10 pages, 2012.

A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives

Received09 Aug 2011
Accepted04 Oct 2011


Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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