Synthesis of Novel N¹ and N² Indazole Derivatives

Abstract

The alkylation of 5-cyano indazoles 2 in the presence of readily available imidizolium salts (ionic liquids) (Bmim)BF₄ as phase transfer catalyst were performed to afford the regio isomers N¹-and N²-(substituted alkyl)-5-cyano indazoles. The N¹-alkylated cyano indazoles were converted to the corresponding N¹-(substituted alkyl)-5-aminomethyl and 5-carbaldehydes 5(a-f) and 6(a-f).