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E-Journal of Chemistry
Volume 9, Issue 3, Pages 1047-1052
http://dx.doi.org/10.1155/2012/198615

Microwave-Assisted, One-Pot Three Component Synthesis of 2-Phenyl H-imidazo[1,2-α]pyridine

1Department of Applied Chemistry, Islamic Azad University, Tehran South Branch, Tehran, Iran
2Industrial faculty, Islamic Azad University, Tehran South Branch, Tehran, Iran
3Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran

Received 5 November 2011; Accepted 7 January 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A novel synthesis of 2-phenylH-imidazio[1,2-α] pyridines is described from a one-pot, three-component reaction between pyridine, guanidine (urea or thiourea) and α-bromoketones under microwave irradiation and solvent-free conditions in excellent yields.