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E-Journal of Chemistry
Volume 9, Issue 1, Pages 175-180

Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives

Sanjeevan S. Gaikwad,1 Venkat S. Suryawanshi,2 Kishan S. Lohar,1 Dhanaji V. Jadhav,3 and Narayan D. Shinde2

1Dept. of Chemistry, Shrikrishna College, Gunjoti, Tal-Omerga, Dist-Osmanabad, Maharashtra-413613, India
2Dept. of Chemistry, PG studies and Research Center, Shri Chattrapati Shivaji College, Omerga, Maharashtra-413 606, India
3Dept. of Chemistry, Y. C. Arts & Science College, Mangrulpir, Dist-Washim, Maharashtra-444 403, India

Received 25 June 2011; Accepted 13 August 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR, 1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.