Journal of Chemistry

Journal of Chemistry / 2012 / Article

Open Access

Volume 9 |Article ID 291850 | 12 pages | https://doi.org/10.1155/2012/291850

Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand

Received29 May 2011
Accepted05 Aug 2011

Abstract

A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS, 1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2 type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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