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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1760-1772

Synthesis and Biological Evaluation of Mannich Bases of Isoxazoline Derivatives as Novel Anti-Microbial Agents

Department of Pharmaceutical Chemistry, PDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, India

Received 4 August 2011; Accepted 19 October 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel series of compounds were synthesized by condensation reaction of substituted acetophenone (1a-b) with substituted aldehyde (2a-b) in presence of alcoholic sodium hydroxide to get intermediate chalcones (3a-c), which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazolines derivatives (4a-c). The latter were refluxed with substituted primary amines and formaldehyde for 6-10 h to afford Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1HNMR) data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method and Minimum Inhibitory Concentration by broth dilution method.