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Versatile Microwave-Assisted and Lanthanum Chloride Catalysed Synthesis of Polysubstituted Imidazoles Using Urea/Thiourea as Benign Source of Ammonia
Mohammad Reza Manafi
,1 Pedram Manafi,2 and Mohammad Reza Kalaee31Department of Applied Chemistry, Islamic Azad University, South Tehran Branch, Tehran, Iran
2Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran
3Department of Polymer Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran
Abstract
Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification.
Copyright
Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
