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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1810-1815

Synthesis and Analgesic Studies of Some New 2-pyrazolines

1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Secunderabad, India
2University College of Pharmaceutical Sciences, Andhra University, Vishakapatanam, India

Received 7 July 2011; Accepted 20 September 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of 2-pyrazolines (4a-j) were synthesized by reacting chalcones (3a-j) with phenyl hydrazine in the presence of pyridine and ethanol. All these compounds were characterized by means of their IR, 1H-NMR spectral data and microanalyses. When these compounds were evaluated for analgesic activity, some of them were found to possess significant activity, when compared to standard drugs.