Vijay S. Patil, Kamlakar P. Nandre, Amulrao U. Borse, Sidhanath V. Bhosale, "InCl3-Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation", Journal of Chemistry, vol. 9, Article ID 615891, 8 pages, 2012. https://doi.org/10.1155/2012/615891
InCl3-Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation
A series of 5-substituted 1H-tetrazole were efficiently prepared by InCl3 catalyzed (10 mol %) from structurally divert organic nitriles with sodium azide under the influence of microwave irradiation. The present protocol was successfully applied to the aliphatic, aryl, benzylic and heterocyclic nitriles and corresponding 5-substituted 1H-tetrazole were obtained in good to excellent yield (70-96%). This method gives remarkable advantages such as short reaction time, simple work-up procedure and economical beneficial.
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